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KMID : 0366219890240020489
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Korean Journal of Hematology
1989 Volume.24 No. 2 p.489 ~ p.496
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Two Cases of Variant Chromosome Translocations in CML
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장준/Joon Jang
윤일국/김종완/송민호/김민범/박철신/김삼용/Il Kuk Youn/Jong Wan Kim/Min Ho Song/Min Bum Kim/Cheal Shin Park/Sam Yong Kim
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Abstract
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Bone marrow cells from approximately 90% of patients who have clinically typical
CML contain the ph' chromosome, identified by Rowley(1973) as the reciprocal
translocation between the between long arm segment of chromosome 22 and the long
arm of chromosome 9.
In a recent review of CML patients, the 9 : 22 translocation was identified in 92%,
however variant translocations have been discovered in addition to the typical t(9 ; 22).
These were thought to be of two kinds : one appeared to be a simple translocation
involving No.22 and some chromosome other than No.9(about 4%), and the other was a
complex translocation involving three or more different chromosomes, two of which were
No.9 and No.22 (about 4%).
Recently, the authors experienced two cases of variant translocations in CML patients,
one is simple translocation t(17 ; 22), the other is complex translocation t(1 ; 19 ; 22).
So we report these cases with brief review of literature.
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KEYWORD
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